Product Info Summary
SKU: | PA1550 |
---|---|
Size: | 100 μg/vial |
Reactive Species: | Human |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-Guanylate-binding protein 1 GBP1 Antibody
SKU/Catalog Number
PA1550
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-Guanylate-binding protein 1 GBP1 Antibody catalog # PA1550. Tested in WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Guanylate-binding protein 1 GBP1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1550)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human GBP1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA1550 is reactive to GBP1 in Human
Applications
PA1550 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
67.931kDa
Background of GBP1
Interferons induce a large number of genes in their target cells, including those coding for guanylate-binding proteins (GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. The 593-amino acid GBP1 protein shares 77% and 88% identity with GBP2 and GBP3, respectively. All GBPs, including GBP1, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T (L/V)RD sequence not found in other GTPases. The GBP1 gene to the GBP gene cluster on chromosome 1p22.2. It is located telomeric to GBP2 and centromeric to GBP3. High expression of GBP1, GBP2, and GBP3 are in endothelial cells after stimulation with IFNG, TNF, or IL1B .
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Reconsitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blot, 0.1-0.5μg/ml, Human
Validation Images & Assay Conditions
Click image to see more details
Anti-GBP1 antibody, PA1550, Western blotting
All lanes: Anti GBP1 (PA1550) at 0.5ug/ml
Lane 1: U87 Whole Cell Lysate at 40ug
Lane 2: HELA Whole Cell Lysate at 40ug
Lane 3: MCF-7 Whole Cell Lysate at 40ug
Predicted bind size: 68KD
Observed bind size: 68KD
Protein Target Info & Infographic
Gene/Protein Information For GBP1 (Source: Uniprot.org, NCBI)
Gene Name
GBP1
Full Name
Guanylate-binding protein 1
Weight
67.931kDa
Superfamily
TRAFAC class dynamin-like GTPase superfamily
Alternative Names
GBP-1; GTP-binding protein 1; Guanine nucleotide-binding protein 1; guanylate binding protein 1, interferon-inducible; guanylate binding protein 1, interferon-inducible, 67kDa; huGBP-1; interferon-induced guanylate-binding protein 1 GBP1 guanylate binding protein 1 guanylate-binding protein 1|GBP-1|GTP-binding protein 1|guanine nucleotide-binding protein 1|guanylate binding protein 1, interferon-inducible, 67kDa|huGBP-1|interferon-induced guanylate-binding protein 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GBP1, check out the GBP1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GBP1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Guanylate-binding protein 1 GBP1 Antibody (PA1550)
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No publications found for PA1550
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Customer Reviews
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Customer Q&As
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1 Customer Q&As for Anti-Guanylate-binding protein 1 GBP1 Antibody
Question
We are currently using anti-GBP1 antibody PA1550 for human tissue, and we are happy with the WB results. The species of reactivity given in the datasheet says human. Is it likely that the antibody can work on goat tissues as well?
Verified Customer
Verified customer
Asked: 2020-02-14
Answer
The anti-GBP1 antibody (PA1550) has not been validated for cross reactivity specifically with goat tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in goat you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2020-02-14